Cytokeratin 18 (CK18) is present in simple, glandular, and transitional epithelial cells, but is absent in stratified epithelial cells. CK18 usually multimerizes with Cytokeratin 8, and Anti-Cytokeratin 18 is useful for detecting adenocarcinomas of simple and glandular epithelium origin, as well as poorly differentiated squamous carcinoma cells.
Moll R. Subcell Biochem. 1998; 31:205-62. Ku NO, et al. J Clin Invest. 1997; 99:19-23. Woelfle U, et al. Clin Cancer Res. 2004; 10:2670-4.
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