产品详情
产品名称IDH1 R132H Antibody
来源种属Mouse
克隆性Monoclonal
克隆性IHC132
应用IHC
种属反应性Human
配方Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
保存Store at 2-8C. Do not freeze.
应用详情
Recommended
working dilution range:1:100 - 1:200
产品描述
Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumours, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma.
背景文献
Cui D, et al. Int J Biochem Cell Biol. 2016;71:72-81.
Balss J, et al. Acta Neuropathol. 2008; 116:597-602.
Capper D, et al. Brain Pathol. 2010; 20:245-54.
Camelo-Piragua S, et al. Acta Neuropathol. 2010; 119:509-11.
2-4 weeks
