产品详情
产品名称JNK1+JNK3 Conjugated Antibody
来源种属Rabbit
克隆性Monoclonal
应用WB, IF
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
别名c Jun N terminal kinase 3 antibody c Jun N-terminal kinase 1 antibody JNK 46 antibody JNK antibody JNK1 antibody JNK1A2 antibody JNK21B1/2 antibody JNK3 alpha protein kinase antibody JNK3 antibody JNK3A antibody JUN N terminal kinase antibody MAP kinase 10 antibody MAP kinase 8 antibody MAP kinase p49 3F12 antibody MAPK 10 antibody MAPK10 antibody MAPK8 antibody Mitogen activated protein kinase 10 antibody Mitogen activated protein kinase 8 antibody Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody p493F12 antibody p54bSAPK antibody PRKM10 antibody PRKM8 antibody SAPK1 antibody SAPK1b antibody SAPK1c antibody Stress activated protein kinase 1 antibody Stress activated protein kinase 1b antibody Stress activated protein kinase 1c antibody Stress activated protein kinase beta antibody Stress activated protein kinase JNK3 antibody
数据库入口号Swiss-Prot#:P45983
计算分子量48 kDa
配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
保存Store at 4˚C in dark for 6 months
应用详情
WB: 1:50-1:200
IF:1:50-1:200
背景
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
1-2 weeks
