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FIP1L1 Polyclonal Antibody#30835

FIP1L1 Polyclonal Antibody
FIP1L1 Polyclonal Antibody
FIP1L1 Polyclonal Antibody
是否有货: Yes
产品总价:
产品详情

产品名称FIP1L1 Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC,IF

种属反应性Hu,Ms,Rt

免疫原描述Recombinant fusion protein of human FIP1L1 (NP_001128409.1).

别名FIP1L1; FIP1; Rhe; hFip1; pre-mRNA 3'-end-processing factor FIP1

数据库入口号Swiss-Prot#:Q6UN15
NCBI Gene ID:81608

计算分子量75kDa

配方Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

保存Store at -20˚C

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using FIP1L1 antibody.
Immunohistochemistry of paraffin-embedded mouse liver using FIP1L1 antibody.
Immunofluorescence analysis of A549 cells using FIP1L1 antibody.
背景
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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025-58868422

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techcn@signalwayantibody.com