产品名称Recombinant 2019-nCoV S1 Protein

简述Recombinant Proteins

纯化Greater than 85% as determined by reducing SDS-PAGE.

生物活性Immobilized Human ACE-2-Fc at 10μg/ml (100 μl/well) can bind 2019-nCoV S1 Protein: Biotinylated by NHS-biotin prior to testing. The ED50 of 2019-nCoV S1 Protein is 1.18 ug/ml.

别名S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein

数据库入口号Uniprot ID: QHD43416.1

计算分子量78.3kDa

保存Reconstituted protein solution should be stored at <-20˚C.

Expression Region: Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed.

Relevance: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Storage Buffer: Supplied as a 0.2 μM filtered solution of PBS, pH 7.4