产品详情
产品名称OTUD7B Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC
种属反应性Hu Ms
特异性The antibody detects endogenous levels of total OTUD7B protein.
免疫原类型peptide
免疫原描述Synthetic peptide corresponding to internal residues of human OTUD7B
基因/蛋白名称OTUD7B
别名ZA20D1; CEZANNE
数据库入口号Swiss-Prot:Q6GQQ9
NCBI Gene ID:56957
NCBI Protein:NP_064590
浓度1.3mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46637(OTUD7B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 46637(OTUD7B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
背景
OTUD7B (OTU domain-containing protein 7B), also known as ZA20D1 or Cezanne, is an 843 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in a variety of tissues, including liver, kidney, heart and immature B-cells, OTUD7B functions to hydrolyze branched and linear forms of polyubiquitin, specifically deubiquinating Lys-48- and Lys-63-linked polyubiquitin chains. Via its ability to deubiquinate target proteins, OTUD7B regulates the inflammatory response within the cell and may play a role in cell survival. More specifically, OTUD7B forms a negative feedback loop in pro-inflammatory signaling, thereby suppressing NF?B activity and helping to resolve inflammatory responses. OTUD7B contains one C-terminal A20-type zinc finger, one OTU domain and one N-terminal TRAF-binding domain through which it conveys its deubiquitinating activity.