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位置: 首页 > 磷酸化抗体 > SCAP (Phospho-Tyr300) Antibody

SCAP (Phospho-Tyr300) Antibody#SAB626

是否有货: Yes
产品总价:
产品详情

产品名称SCAP (Phospho-Tyr300) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化The antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

应用WB

种属反应性Human,Mouse

特异性SCAP(Phospho-Tyr300) Antibody detects endogenous levels of SCAP only when phosphorylated at Tyr300.

免疫原描述A synthesized peptide derived from human SCAP around the phosphorylation site of Tyr300.

别名SCAP,SREBP cleavage-activating protein,KIAA0199,PSEC0227

UniprotQ12770

Gene ID22937

实际分子量139kDa

浓度1 mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.

保存Store at --20˚C/1 year

应用详情
Western Blot: 1/500 - 1/2000
背景
Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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