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位置: 首页 > 抑制剂 > Acetylsalicylic acid

Acetylsalicylic acid#S0005

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Acetylsalicylic acid

简述Inhibitors

纯化99.12%

生物活性Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of Ys including prostate Y, breast Y, colorectal Y, endometrial Y, and ovarian Y. Aspirin suppresses ovarian Y cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively.

基因/蛋白名称COX inhibitor

CAS号50-78-2

计算分子量180.16

配方C9H8O4

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Nervous system
SMILES:CC(=O)OC1=CC=CC=C1C(O)=O
Pathways:Immunology/Inflammation; Neuroscience
Receptor:COX-1; COX-2
Boling pt:140C
Melting pt:134-136C
Solubility:Ethanol: 36 mg/mL (199.82 mM); DMSO: 36 mg/mL (199.82 mM)
Appearance:White Crystal
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Kopp E, et al. Science, 1994, 265(5174), 956-959.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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