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位置: 首页 > 抑制剂 > Nicorandil

Nicorandil#S0075

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Nicorandil

简述Inhibitors

纯化99.44%

生物活性Nicorandil(Ikorel)is potassium channel activator. It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.

基因/蛋白名称Potassium Channel activator

CAS号65141-46-0

计算分子量211.18

配方C8H9N3O4

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Cardiovascular System
SMILES:[O-][N+](=O)OCCNC(=O)C1=CN=CC=C1
Pathways:Membrane transporter/Ion channel
Receptor:Potassium Channel
Boling pt:456.7C?
Melting pt:92C
Solubility:Ethanol: 42 mg/mL (198.89 mM); Water: 17 mg/mL (80.5 mM); DMSO: 42 mg/mL (198.89 mM)
Appearance:White Cotton Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Kandabashi T, et al. Circulation. 2000 Mar 21;101(11):1319-23.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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