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位置: 首页 > 抑制剂 > Pazopanib

Pazopanib#S0097L

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Pazopanib

简述Inhibitors

纯化98.78%

生物活性Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

基因/蛋白名称c-Kit inhibitor; PDGFR inhibitor; VEGFR inhibitor

CAS号444731-52-6

计算分子量437.52

配方C21H23N7O2S

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Other
SMILES:CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=NC(NC2=CC(=C(C)C=C2)S(N)(=O)=O)=NC=C1
Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
Receptor:c-Kit; PDGFR; VEGFR1; VEGFR2; VEGFR3
Boling pt:
Melting pt:
Solubility:DMSO: 87 mg/mL warmed (198.84 mM)
Appearance:White Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Harris PA, et al. J Med Chem. 2008, 51(15), 4632-4640.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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