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位置: 首页 > 抑制剂 > Quetiapin

Quetiapin#S0162

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Quetiapin

简述Inhibitors

纯化99.50%

生物活性Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

基因/蛋白名称5-HT Receptor antagonist; AChR antagonist; Adrenergic Receptor antagonist; Dopamine Receptor antagonist; Histamine Receptor antagonist

CAS号111974-69-7

计算分子量383.51

配方C21H25N3O2S

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Nervous system
SMILES:OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C12
Pathways:GPCR/G Protein; Neuroscience; Immunology/Inflammation
Receptor:5-HT; mAChR; Adrenergic Receptor; Dopamine; H1 receptor
Boling pt:556.5C?
Melting pt:172-174C
Solubility:DMSO: 36 mg/mL;Water: <1 mg/mL
Appearance:White Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Nasrallah HA. Mol Psychiatry. 2008 Jan;13(1):27-35.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
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  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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