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位置: 首页 > 抑制剂 > Sunitinib Malate

Sunitinib Malate#S0374

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Sunitinib Malate

简述Inhibitors

纯化98.00%

生物活性Potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor. Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

基因/蛋白名称FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor

CAS号341031-54-7

计算分子量532.56

配方C26H33FN4O7

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述

Research Area:Cancer
SMILES:CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
Receptor:FGFR1; PDGFRβ; VEGFR2
Boling pt:
Melting pt:189-191C
Solubility:DMSO: 15 mg/mL (28.16 mM)
Appearance:Orange Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

背景文献

1. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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