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位置: 首页 > 抑制剂 > PF-477736

PF-477736#S6028

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产品总价:询价
产品详情

产品名称PF-477736

简述Inhibitors

纯化98.34%

生物活性PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1.

基因/蛋白名称c-Fms inhibitor; Chk inhibitor; Src inhibitor; VEGFR inhibitor

CAS号952021-60-2

计算分子量419.48

配方C22H25N7O2

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Cancer
SMILES:CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N
Pathways:Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
Receptor:c-Fms; Chk1; Chk2; Yes; VEGFR2
Boling pt:
Melting pt:
Solubility:DMSO:6 mg/mL (14.3 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Blasina A, et al. Mol Y Ther, 2008, 7(8), 2394-2404.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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