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位置: 首页 > 抑制剂 > Quisinostat (JNJ-26481585)

Quisinostat (JNJ-26481585)#S6055

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Quisinostat (JNJ-26481585)

简述Inhibitors

纯化99.00%

生物活性Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.

基因/蛋白名称HDAC inhibitor

CAS号875320-29-9

计算分子量394.476

配方C21H26N6O2

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Cancer
SMILES:CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO
Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
Receptor:HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC8
Boling pt:
Melting pt:
Solubility:DMSO:79 mg/mL (200.26 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Arts J, et al. Clin Cancer Res, 2009, 15(22), 6841-6851.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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