产品详情
产品名称PI-1840
简述Inhibitors
纯化99.50%
生物活性PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).
基因/蛋白名称Proteasome inhibitor
CAS号1401223-22-0
计算分子量394.47
配方C22H26N4O3
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:CCCC1=CC=C(OCC(=O)N(CC2=NC(=NO2)C2=CC=CN=C2)C(C)C)C=C1 |c:15,21,23,29,t:3,5,13,19|
Pathways:Proteases/Proteasome; Ubiquitination
Receptor:Chymotrypsin-like proteasome
Boling pt:
Melting pt:
Solubility:Ethanol: 33 mg/mL (83.65 mM)DMSO: 78 mg/mL (197.73 mM)Water: <1 mg/mL
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Ozcan S, et al. J Med Chem. 2013, 56(10), 3783-3805.
The lead time is currently 7-30 days.
