产品详情
产品名称TRx0237 (LMTX) mesylate
简述Inhibitors
纯化98.00%
生物活性TRx 0237 (LMTX?) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
基因/蛋白名称Microtubule Associated inhibitor
CAS号1236208-20-0
计算分子量477.62
配方C16H19N3S2CH4O3S
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:CS([O-])(=O)=O.CS([O-])(=O)=O.C[NH+](C)C1=CC=C2NC3=C(SC2=C1)C=C(C=C3)[NH+](C)C |c:16,20,23,25,t:11,13|
Pathways:Cytoskeletal Signaling
Receptor:Tau aggregation
Boling pt:
Melting pt:
Solubility:Ethanol<1 mg/mLDMSO: 95 mg/mL (198.9 mM)Water: 95 mg/mL (198.9 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Panza F.,Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother. 2016;17(4):457-61.
The lead time is currently 7-30 days.
