产品详情
产品名称UNC-2025
简述Inhibitors
纯化99.00%
生物活性UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
基因/蛋白名称FLT inhibitor; TAM Receptor inhibitor
CAS号1429881-91-3
计算分子量513.12
配方C28H41ClN6O
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:Cl.CCCCNC1=NC=C2C(=N1)N(C=C2C1=CC=C(CN2CCN(C)CC2)C=C1)C1CC[C@H](O)CC1 |r,c:7,9,13,29,t:5,16,18,@:12|
Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
Receptor:FLT3; AXL; Mer; Tyro3
Boling pt:
Melting pt:
Solubility:Ethanol8 mg/mL warming (15.59 mM)DMSO: 25 mg/mL warming (48.72 mM)Water: 100 mg/mL (194.88 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Zhang W, et al. J Med Chem. 2014, 57(16), 7031-7041.
The lead time is currently 7-30 days.
