产品详情
产品名称Aprataxin Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
克隆性S03-9F6
亚型Rabbit IgG
纯化Affinity Purified
应用WB
种属反应性Human
免疫原描述A synthetic peptide of human Aprataxin
标记Unconjugated
修饰Unmodification
别名AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT
数据库入口号Swiss-Prot:Q7Z2E3
GeneID:54840
UniprotQ7Z2E3
Gene ID54840
计算分子量Calculated MW: 41 kDa; Observed MW: 41 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/1000;
背景
Swiss-Prot Acc.Q7Z2E3.DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) .
Yes
