产品详情
产品名称AXL Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
克隆性S06-5B2
亚型Rabbit IgG
纯化Affinity Purified
应用WB
种属反应性Human,Mouse,Rat
免疫原描述Recombinant protein of human Axl
标记Unconjugated
修饰Unmodification
别名ARK; UFO; JTK11; Tyro7
数据库入口号Swiss-Prot:P30530
GeneID:558
UniprotP30530
Gene ID558
计算分子量Calculated MW: 98 kDa; Observed MW: 138 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/1000
背景
Swiss-Prot Acc.P30530.Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.