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位置: 首页 > 重组兔单抗 > Kaiso Rabbit mAb

Kaiso Rabbit mAb#52379

评价
Recombinant
Kaiso Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称Kaiso Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆性S05-5J5

亚型Rabbit IgG

纯化Affinity Purified

应用WB

种属反应性Human,Mouse,Rat

免疫原描述A synthetic peptide of human Kaiso

标记Unconjugated

修饰Unmodification

别名ZNF348; ZNF-kaiso

数据库入口号Swiss-Prot:Q86T24
GeneID:10009

UniprotQ86T24

Gene ID10009

计算分子量Calculated MW: 75 kDa; Observed MW: 90 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/1000-1/5000
Western blot detection of Kaiso in MCF7,C6 cell lysates using Kaiso Rabbit mAb(1:1000 diluted).Predicted band size:75KDa.Observed band size:90KDa.
背景
Swiss-Prot Acc.Q86T24.Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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