Recombinant Tau(Phospho-Thr217) Rabbit mAb(G122)#58004
产品名称Recombinant Tau(Phospho-Thr217) Rabbit mAb(G122)
种属反应性Hu Ms Rt
特异性The antibody detects endogenous levels of Tau only when phosphorylated at threonione 217.
免疫原描述Peptide sequence around phosphorylation site of threonine 217(L-P-T(p)-P-P) derived from Human Tau.
别名MAPT; MTBT1; PHF-tau;
NCBI Gene#: 4137;
NCBI Protein#: NP_058519.3.
保存Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles.
Western blotting: 1:500~1:1000
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Goedert M., EMBO J. 8:393-399(1989).
Lee G., Neuron 2:1615-1624(1989).