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位置: 首页 > 磷酸化抗体 > CaMKII(Phospho-Thr286) Antibody

CaMKII(Phospho-Thr286) Antibody#11287

CaMKII(Phospho-Thr286) Antibody
CaMKII(Phospho-Thr286) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CaMKII(Phospho-Thr286) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of CaMKII only when phosphorylated at threonine 286.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of threonine 286 (Q-E-T(p)-V-D) derived from Human CaMKII.

基因/蛋白名称CaMKII

修饰Phospho

别名CAMKA

数据库入口号Swiss-Prot: Q9UQM7
NCBI Protein: NP_057065.2

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 50kd
Western blotting: 1:500~1:1000

Western blot analysis of extracts from 293 cells untreated or treated with PMA using CaMKII(Phospho-Thr286) Antibody #11287.
Western blot analysis of extracts from Rat brain tissue treated with Lambda Phosphotase or calf intestinal phosphatase (CIP),using CaMKII (Phospho-Thr286) Antibody#11287.
背景

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity

Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21): 11232-11237
Hudmon A, et al. J Cell Biol. Author manuscript; available in PMC 2006 May 7
Miller P, et al. PLoS Biol. 2005 Apr; 3(4): e107
Runyan JD, et al. Learn Mem. 2005 Mar; 12(2): 103-110.

如果您使用该产品11287发表了文章,请通知我们,让我们可以引用您的文献。

et al,Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury. In World J Diabetes on 2022 Apr 15 by Shi-Jun Jiang,et al..PMID:35582666, , (2022),
PMID: 35582666
et al,Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homoeostasis.In Basic Clin Pharmacol Toxicol on 2020 Feb; by Ma W, Liu M, et al..PMID:31483925, , (2020),
PMID: 31483925
et al,Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin鈥恉ependent protein kinase II pathway.In Br J Pharmacol on 2015 Dec by Xing-Zhu Lu, Xue-Yuan Bi et al..PMID: 25953628, , (2015),
PMID: 25953628
et al,Mechanisms underlying a decrease in KCl-induced contraction after long-term serum-free organ culture of rat isolated mesenteric artery.In J Vet Med Sci on 2014 Jul by Tomoka Morita, Muneyoshi Okada et al..PMID: 24694942, , (2014),
PMID: 24694942
et al, HIV subtypes B and C gp120 and methamphetamine interaction: dopaminergic system implicates differential neuronal toxicity.In Sci Rep on 2015 Jun 9 by Thangavel Samikkannu, Kurapati V K Rao et al..PMID: 26057350, , (2014),
PMID: 26057350
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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