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位置: 首页 > 磷酸化抗体 > MEF2a(Phospho-Ser408) Antibody

MEF2a(Phospho-Ser408) Antibody#11309

MEF2a(Phospho-Ser408) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称MEF2a(Phospho-Ser408) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用IHC

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of MEF2A only when phosphorylated at serine 408.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 408 (P-I-S(p)-P-P) derived from Human MEF2A.

基因/蛋白名称MEF2a

修饰Phospho

别名MEF2; Serum response factor-like protein 1;

数据库入口号Swiss-Prot: Q02078
NCBI Protein: NP_001124398.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 54kd
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MEF2A(Phospho-Ser408) Antibody #11309(left) or the same antibody preincubated with blocking peptide(right).
背景
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain

Okamoto SI, et al. (2002) Proc Natl Acad Sci USA; 99(6): 3974-3979.
Quinn ZA, et al. (2001) Nucleic Acids Res; 29(3): 732-742.
Kato Y, et al. (2000) J Biol Chem. 275(24): 18534-18540.
De Angelis L, et al. (1998) Proc Natl Acad Sci USA; 95(21): 12358-12363.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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