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位置: 首页 > 磷酸化抗体 > TrkB(Phospho-Tyr705) Antibody

TrkB(Phospho-Tyr705) Antibody#11328

TrkB(Phospho-Tyr705) Antibody
TrkB(Phospho-Tyr705) Antibody
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产品总价:
产品详情

产品名称TrkB(Phospho-Tyr705) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.

基因/蛋白名称TrkB

修饰Phospho

别名BDNF/NT-3 growth factors receptor precursor; EC 2.7.10.1; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2

数据库入口号Swiss-Prot: Q16620
NCBI Protein: NP _001007098.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 140kd
Western blotting: 1:500~1:1000

Western Blot analysis of 293 cells using Phospho-Trk B (Y706) Polyclonal Antibody .
Immunofluorescence analysis of Hela cell.
背景

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.
Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.
Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.
Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.

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et al,VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosisIn Neurobiol DisOn2023 Oct 15byEsther García-García , Alba Ramón-Lainez et al..PMID:37714309, , (2023),
PMID: 37714309
et al,Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexityInJ Extracell VesiclesOn2023 SepbyJulia Solana-Balaguer , Genís Campoy-Campos et al..PMID:37743539, , (2023),
PMID: 37743539
et al,17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. In Psychoneuroendocrinology on 2021 Mar by Kellie S Gross, Randie L Alf, et al..PMID:33352471, , (2021),
PMID: 33352471
et al,Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior .In Front Pharmacol. On 2018 Aug 6 by Moreno S, Devader CM et al..PMID:30127743, , (2018),
PMID: 30127743
et al,Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental Two-Hit Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation.In Front Behav Neurosci On 2018 Oct 9 by Adrienne M. Grech, Udani Ratnayake et al..PMID: 30356704, , (2018),
PMID: 30356704
et al,Chronic Intermittent Hypobaric Hypoxia Pretreatment Ameliorates Ischemia-Induced Cognitive Dysfunction Through Activation of ERK1/2-CREB-BDNF Pathway in Anesthetized Mice.In Neurochem Res on 2017 Feb by Jintian Wang , Shixiao Zhang,et al..PMID: 27822668, , (2017),
PMID: 27822668
et al,ER伪 Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy. In eNeuro on 2016 Jan 28 by Ulas Cikla, Vishal Chanana, et al..PMID: 26839918, , (2016),
PMID: 26839918
查看更多
et al,A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. In Neuropharmacology on 2016 Nov by Tao Yang, Stephen M Massa,et al..PMID:27334657, , (2016),
PMID: 27334657
et al,Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment. In Neuroscience on 2015 Jan 22 by A Gururajan, R A Hill,et al..PMID:25445195, , (2015),
PMID: 25445195
et al,High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice. In Neurobiol Dis on 2014 Sep by Christina Mo, Terence Y Pang,et al..PMID:24825316, , (2014),
PMID: 24825316
et al,Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain.In Biochim Biophys Acta on 2014 Nov by Rachel A Hill, Szerenke Kiss Von Soly ,et al..PMID:25159716, , (2014),
PMID: 25159716
et al,Sex鈥恠pecific disruptions in spatial memory and anhedonia in a 鈥渢wo hit锟?rat model correspond with alterations in hippocampal brain鈥恉erived neurotrophic factor expression and signaling. In Hippocampus on 2014 Oct by Rachel A Hill, Maren Klug,et al..PMID:24802968, , (2014),
PMID: 24802968
Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos et al,Sex-denpendent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steriod hormones., Neurochem., 126:389--399 (2013),
PMID: 23414458
et al,Sex鈥恉ependent alterations in BDNF鈥怲rkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones.In J Neurochem on 2013 Aug by Rachel A Hill, Yee-Wen Candace Wu, et al..PMID:23414458, , (2013),
PMID: 23414458
et al,A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. In J Neurosci on 2013 Nov 27 by Tao Yang, Christina Condon, et al..PMID: 24285878, , (2013),
PMID: 24285878
R. A. Hill, Y. W. C. Wu, P. Kwek et al,Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice, Journal of Neuroendocrinology, 24, 774篓C788 (2012),
PMID: 22221196
et al,Sex-specific and region-specific changes in BDNF鈥揟rkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice. In Brain Res on 2012 May 3 by YeeWen Candace Wu, Rachel A Hill, et al..PMID:22464183, , (2012),
PMID: 22464183
Rachel A. Hill, Maarten van den Buuse et al,Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice., Brain Research, 1384:51-60 (2011),
PMID: 21281620
et al,Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. In Brain Res on 2011 Apr 12 by Rachel A Hill, Maarten van den Buuse锟?et al..PMID: 21281620, , (2011),
PMID: 21281620
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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