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CCDC106 Antibody#25162

CCDC106 Antibody
CCDC106 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CCDC106 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Affinity chromatography purified via peptide column

应用ELISA WB IHC

种属反应性Hu Ms Rt

免疫原类型Peptide

免疫原描述Raised against a 15 amino acid peptide near the carboxy terminus of human CCDC106.

基因/蛋白名称CCDC106

别名Coiled-coil domain containing protein 106, ZNF581, HSU79303

数据库入口号NP_037433

UniprotNP_037433

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western blot analysis of CCDC106 in human brain tissue lysate with CCDC106 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of CCDC106 in rat brain tissue with CCDC106 antibody at 5 ug/mL.
背景
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.

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et al,CK2-mediated CCDC106 phosphorylation is required for p53 degradation In cancer progression. In J Exp ClIn Cancer Res on 2019 Mar 18 by NIng Y, Wang C, et al..PMID: 30885251, , (2019),
PMID: 30885251
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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