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位置: 首页 > 抗体 > Tau(Ab-262) Antibody

Tau(Ab-262) Antibody#21100

Tau(Ab-262) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Tau(Ab-262) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms

特异性The antibody detects endogenous level of total Tau protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.260~264 (I-G-S-T-E) derived from Human Tau.

基因/蛋白名称Tau

别名MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau

数据库入口号Swiss-Prot: P10636
NCBI Protein: NP _001116538.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from mouse brain tissue using Tau(Ab-262) Antibody #21100.
背景
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Timm T, et al. (2003) EMBO J; 22(19): 5090-5101.

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et al,Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficitsInAging (Albany NY)On2023 Dec 12byLing Lei?1?2,?Yong Luo et al..PMID:?38095632, , (2023),
PMID: 38095632
et al,Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid 尾42 in mice.In Brain Res on 2015 Aug 27 by Yi-Pei Li, Guo-Jun Yang et al..PMID:26049128, , (2015),
PMID: 26049128
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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