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位置: 首页 > 磷酸化抗体 > CREB(Phospho-Ser142) Antibody

CREB(Phospho-Ser142) Antibody#11300

CREB(Phospho-Ser142) Antibody
CREB(Phospho-Ser142) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CREB(Phospho-Ser142) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB IHC

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of CREB only when phosphorylated at serine142.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 142(D-L-S(p)-S-D) derived from Human CREB.

基因/蛋白名称CREB

修饰Phospho

别名CREB

数据库入口号Swiss-Prot: P16220; NCBI Gene ID: 1385; NCBI mRNA: NM_004379.3; NCBI Protein: NP_004370.1

UniprotP16220

实际分子量43KD

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C

应用详情
 Predicted MW: 43kd
 Immunohistochemistry: 1:50~1:100 
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Phospho-Ser142) Antibody (#11300).
Western blot analysis of extracts from 293 cells, treated with calf intestinal phosphatase (CIP), using CREB(Phospho-Ser142) Antibody #11300.
背景

 Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

如果您使用该产品11300发表了文章,请通知我们,让我们可以引用您的文献。

et al,Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders. In Front Neurol on 2020 Nov 25 by Irma E Cisneros, Anuja Ghorpade, et al..PMID:33324330, , (2020),
PMID: 33324330
Tomasz Boczek, Anna Kozaczuk, Bozena Ferenc et al,Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin, Mol Cell Biochem, 360(1-2):89-102 (2012),
PMID: 21912933
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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