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位置: 首页 > 抗体 > Bax (Ab-167) Antibody

Bax (Ab-167) Antibody#33148

Bax (Ab-167) Antibody
Bax (Ab-167) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Bax (Ab-167) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

应用WB IF

种属反应性Hu Ms

特异性The antibody detects endogenous levels of total Bax protein

免疫原类型Peptide

免疫原描述Synthesized non-phosphopeptide derived from human Bax around the phosphorylation site of threonine 167 (F-G-T(p)-P-T).

基因/蛋白名称Bax

别名Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;

数据库入口号Swiss-Prot: Q07812
NCBI Gene ID: 581

UniprotQ07812

实际分子量21kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500
Western blot analysis of extracts from HepG2 cells, using Bax (Ab-167) antibody #33148.
Immunofluorescence analysis of LOVO cells, using Bax (Ab-167) antibody #33148.
背景
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Oltvai Z.N., Cell 74:609-619(1993).
Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001).
Guo B., Nature 423:456-461(2003)

如果您使用该产品33148发表了文章,请通知我们,让我们可以引用您的文献。

et al,Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents.On Br J Cancer.On 2014 Apr 29 by Saha MN, Chen Y et al..PMID:24691427, , (2014),
PMID: 24691427
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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