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IRS-1 (Ab-312) Antibody#33191

IRS-1 (Ab-312) Antibody
IRS-1 (Ab-312) Antibody
IRS-1 (Ab-312) Antibody
IRS-1 (Ab-312) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IRS-1 (Ab-312) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

应用WB IHC IF

种属反应性Hu Ms

特异性The antibody detects endogenous levels of total IRS-1 protein.

免疫原类型Peptide

免疫原描述Synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A).

基因/蛋白名称IRS-1

别名Insulin receptor substrate-1; IRS-1; IRS1;

数据库入口号Swiss-Prot: P35568
NCBI Gene ID: 3667

UniprotP35568

实际分子量180kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 (Ab-312) antibody #33191.
Immunofluorescence analysis of HeLa cells, using IRS-1 (Ab-312) antibody #33191.
Western blot analysis of extracts from NIH-3T3 cells, using IRS-1 (Ab-312) antibody #33191.
Western blot analysis of extracts from JK cells (Lane 2), using IRS-1 (Ab-312) antiobdy #33191. The lane on the left is treated with synthesized peptide.
背景
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.

Araki E., Diabetes 42:1041-1054(1993).
Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).
The MGC Project Team; Genome Res. 14:2121-2127(2004)

如果您使用该产品33191发表了文章,请通知我们,让我们可以引用您的文献。

et al,Liraglutide Ameliorates HyperhomocysteInemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular TargetIng. In Neurosci Bull on 2019 Jan 10 by Zhang Y, Xie JZ, et al..PMID: 30632006, , (2019),
PMID: 30632006
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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