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位置: 首页 > 标记抗体 > QK1 Polyclonal Antibody Cy5 Conjugated

QK1 Polyclonal Antibody Cy5 Conjugated#C01318Cy5

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产品总价:
产品详情

产品名称QK1 Polyclonal Antibody Cy5 Conjugated

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Purified by Protein A.

应用IF(IHC-P)

种属反应性Hu Ms Rt

免疫原描述KLH conjugated synthetic peptide derived from human QK1

标记Cy5

激发/发射波长625,650nm 670nm

基因/蛋白名称QK1

别名HKQ; Homolog of mouse quaking QKI KH domain RNA binding protein; Hqk; HQK1; HqkI; Protein quaking; QK; QK1; QK3; QKI; QKI_HUMAN; QKI1; Quaking homolog; Quaking homolog KH domain RNA binding; Quaking homolog KH domain RNA binding mouse; Quaking isoform 1; Quaking protein; RNA binding protein HQK.

浓度1mg ml

配方Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

保存 Store at 4C for 12 months.

应用详情
IF:1:50-200
背景
QKI is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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