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NMDANR2B Subunit Antibody#21560

NMDANR2B Subunit Antibody
是否有货: 有货
产品总价:
产品详情

产品名称NMDANR2B Subunit Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of total NMDANR2B Subunit protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.1250-1254(N-L-Y-D-I) derived from Human NMDANR2B Subunit.

基因/蛋白名称NMDANR2B Subunit

别名NMDAR2B; NR2B;

数据库入口号Swiss-Prot: Q00960
NCBI Protein: NP_036706.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 180kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from T98G cells using NMDANR2B Subunit Antibody #21560
背景
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death

Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.Science 269:1737-1740(1995)
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.Mol. Cell. Neurosci. 11:161-172(1998)

如果您使用该产品21560发表了文章,请通知我们,让我们可以引用您的文献。

et al,Bisphenol-A Induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons Chemosphere. In Chemosphere on 2019 Aug by Wang H, Zhao P, et al..PMID: 31102917, , (2019),
PMID: 31102917
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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