产品详情
产品名称ABCA1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of total ABCA1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.2253~2257(D-E-K-V-K) derived from Human ABCA1.
基因/蛋白名称ABCA1
别名TGD; ABC1; CERP; ABC-1;
数据库入口号Swiss-Prot: O95477
NCBI Protein: NP_005493.2
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 254kd
Western blotting: 1:500~1:1000
背景
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Kaplan R., Gan X., Menke J.G. Lipid Res. 43:952-959(2002)
Hamon Y., Trompier D., Ma Z., Venegas V. PLoS ONE 1:E120-E120(2006)
Singaraja R.R., Kang M.H., Vaid K. Berthiaume L. Res. 105:138-147(2009)
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et al,Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.In Molecules on 2015 Dec 1 by Shuangying Hao, Jiajie Ji et al..PMID: 26633327,
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et al,22 (R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPAR纬鈥揕XR伪鈥揂BCA1 pathway in cholesterosis of the gallbladder.In Biochem Biophys Res Commun on 2014 Apr 25 by Jing-Min Wang, Dong Wang et al..PMID:24704452 ,
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