YPEL5 (yippee-like 5), also known as CGI-127, is a 121 amino acid protein that may be involved in cell division-related function. During cell cycle progression, YPEL5 localizes to multiple subcellular regions. At interphase of mitosis, YPEL5 localizes to the nucleus and centrosome, then changes its location sequentially to the spindle poles, mitotic spindle and spindle midzone, and finally it is transferred to the midbody at cytokinesis. The function of YPEL5 during cell division is not yet fully understood.