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IGF-1R(Ab-1280) Antibody

21302
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  货号 规格 价格
21302-1 50ul ¥1200.00元
21302-2 100ul ¥2000.00元

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产品详情
  • 产品名称 IGF-1R(Ab-1280) Antibody
  • 来源种属 Rabbit
  • 克隆性 Polyclonal
  • 纯化 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 应用 WB IHC
  • 种属反应性 Hu Ms
  • 特异性The antibody detects endogenous level of total IGF-1R protein.
  • 免疫原类型Peptide-KLH
  • 免疫原描述 Peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .
  • 基因/蛋白名称 IGF-1R
  • 别名 Insulin-like growth factor I receptor
  • 数据库入口号 Swiss-Prot: P08069
    NCBI Protein: NP_000866.1
  • 浓度 1.0mg/ml
  • 配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 保存 Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情

Predicted MW: 200 95 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

图片
  • IGF-1R(Ab-1280) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from 293,3T3 and Hela cells using IGF-1R(Ab-1280) Antibody #21302.

  • IGF-1R(Ab-1280) Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R(Ab-1280) Antibody #21302(left) or the same antibody preincubated with blocking peptide(right).

背景
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
Baserga, R. et al. (2000) Oncogene 19, 5574-5581
Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
O'Connor R, et al. Mol Cell Biol 1997 Jan; 17(1): 427-35
  • et al,Sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus.In Brain Struct Funct on 2012 Apr by Hami J, Sadr-Nabavi A,et al..PMID:22042446, , (2012),
    PMID: 22042446
  • et al,Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer.In Exp Ther Med on 2012 May by Yamamoto T, Oshima T,et al..PMID:22969971, , (2012),
    PMID: 22969971
  • 如果您使用该产品21302发表了文章,请 通知我们 ,让我们可以引用您的文献。
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      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
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    • ChIP染色质免疫沉淀
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