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位置: 首页 > 抗体 > IGF-1R(Ab-1280) Antibody

IGF-1R(Ab-1280) Antibody#21302

IGF-1R(Ab-1280) Antibody
IGF-1R(Ab-1280) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IGF-1R(Ab-1280) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB IHC

种属反应性Hu Ms

特异性The antibody detects endogenous level of total IGF-1R protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .

基因/蛋白名称IGF-1R

别名 Insulin-like growth factor I receptor

数据库入口号Swiss-Prot: P08069
NCBI Protein: NP_000866.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 200 95 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from 293,3T3 and Hela cells using IGF-1R(Ab-1280) Antibody #21302.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R(Ab-1280) Antibody #21302(left) or the same antibody preincubated with blocking peptide(right).
背景
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
Baserga, R. et al. (2000) Oncogene 19, 5574-5581
Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
O'Connor R, et al. Mol Cell Biol 1997 Jan; 17(1): 427-35

如果您使用该产品21302发表了文章,请通知我们,让我们可以引用您的文献。

et al,Sex differences and left-right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus.In Brain Struct Funct on 2012 Apr by Hami J, Sadr-Nabavi A,et al..PMID:22042446, , (2012),
PMID: 22042446
et al,Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer.In Exp Ther Med on 2012 May by Yamamoto T, Oshima T,et al..PMID:22969971, , (2012),
PMID: 22969971
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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