产品详情
产品名称IRS-1(Phospho-Ser312) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.
基因/蛋白名称IRS-1
标记Unconjugated
别名HIRS-1; IRS1; Insulin receptor substrate 1
数据库入口号Swiss-Prot: P35568
NCBI Protein: NP_005535.1
Uniprot
P35568
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 180kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from 293 cells untreated or treated with insulin using IRS-1(Phospho-Ser312) antibody #11143.
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645
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et al,Liraglutide Ameliorates HyperhomocysteInemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular TargetIng. In Neurosci Bull on 2019 Jan 10 by Zhang Y, Xie JZ, et al..PMID: 30632006
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30632006
et al,Exploration of the lactation function of protein phosphorylation sites in goat mammary tissues by phosphoproteome analysis
, (2021),
PMID:
34583635
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