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位置: 首页 > 磷酸化抗体 > TYK2(Phospho-Tyr1054/1055) Antibody

TYK2(Phospho-Tyr1054/1055) Antibody#11148

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产品详情

产品名称TYK2(Phospho-Tyr1054/1055) Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

应用WB

种属反应性Human;Mouse;Rat

特异性This antibody detects endogenous levels of Tyk2 only when phosphorylated at Tyr1054 or tyr1055,and dually phosphorylated at two sites.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2.

基因/蛋白名称TYK2

标记Unconjugated

别名tyrosine kinase 2; JTK1;

数据库入口号Swiss-Prot: P29597
NCBI Protein: NP_003322.3

Uniprot P29597

浓度1.0mg/ml

配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
WB 1:1000 - 1:2000
Western blot analysis of extracts from HT29 cells untreated(lane 1) or treated with Anisomycin(lane 2) using TYK2(Phospho-Tyr1054) Antibody #11148.

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

如果您使用该产品11148发表了文章,请通知我们,让我们可以引用您的文献。

et al,6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside Potentiates the Anti-Proliferative Effect of Interferon 伪/尾 by Promoting Activation of the JAK/STAT Signaling by Inhibiting SOCS3 in Hepatocellular Carcinoma Cells.In Toxicol Appl Pharmacol on 2017 Dec 1 by Orawan Wonganan, Yu-Jiao He,et al..PMID: 29031523 , (2017),
PMID: 29031523
et al,Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase , (2017),
PMID: 29371942

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

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