产品详情
产品名称HDAC5(Phospho-Ser498) Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB;IHC;IF
种属反应性Human;Mouse
特异性The antibody detects endogenous level of HDAC5 only when phosphorylated at serine498.
免疫原类型Peptide-KLH
免疫原描述The antiserum was produced against synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498.
基因/蛋白名称HDAC5
标记Unconjugated
别名HD5
数据库入口号Swiss-Prot: Q9UQL6
NCBI Protein: NP_001015053.1
Uniprot
Q9UQL6
浓度1.0mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Western Blot analysis of VEC cells using Phospho-HDAC5 (S498) Polyclonal Antibody diluted at 1:500
Western blot analysis of lysates from Jurkat cells, using HDAC5 (Phospho-Ser498) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using HDAC5 (Phospho-Ser498) Antibody. The picture on the right is blocked with the phospho peptide.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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et al,GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.
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PMID:
18292392
et al,Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.
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PMID:
20181743
et al,Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.
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PMID:
18218981
et al,Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.
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PMID:
20042720
et al,DopamIne receptor antagonists as potential therapeutic agents for ADPKD. In PLoS One on 2019 May 6 by Paul P, Ramachandran S et al.. PMID:31059522
, (2019),
PMID:
31059522
et al,Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.In Blood on 2010 Apr 8 by Weiye Wang, Chang Hoon Ha,et al..PMID:20042720
, (2010),
PMID:
20042720
et al,Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. In Development on 2010 Apr by Sheng Xia, Xiaogang Li, et al..PMID: 20181743
, (2010),
PMID:
20181743
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