产品详情
产品名称Ezrin(Phospho-Thr567) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of Ezrin only when phosphorylated at threonine 567.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of threonine 567 (Y-K-T(p)-L-R) derived from Human Ezrin.
基因/蛋白名称Ezrin
标记Unconjugated
别名Cytovillin; EZRI; VIL2; Villin 2; p81
数据库入口号Swiss-Prot: P15311
NCBI Protein: NP_001104547.1
Uniprot
P15311
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 81kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from MDA cells untreated or treated with anisomycin using Ezrin(Phospho-Thr567) Antibody #11202.
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Zhou R, et al. (2005) J Cell Sci: 118 (Pt 19): 4381-91
Shiue H, et al.(2005) J Biol Chem: 280(2): 1688-95
Zhao H, et al. (2004) Proc Natl Acad Sci U S A: 101(25): 9485-90
Fievet BT, et al. (2004) J Cell Biol: 164(5): 653-9
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et al,Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma.
, (2010),
PMID:
20158339
et al,Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function.In Am J Physiol Renal Physiol on 2020 Feb by Stotter BR, Talbot BE, et al..PMID:31904283
, (2020),
PMID:
31904283
et al,Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma.In Cancer Invest on 2010 Mar by Cui Y1, Li T,et al..PMID:20158339
, (2010),
PMID:
20158339
et al,Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer.In BMC Cancer on 2014 Mar 15 by Tiefeng Jin, Jingchun Jin et al ..PMID: 24629131
, (2014),
PMID:
24629131
et al,Clustered PI (4, 5) P2 accumulation and ezrin phosphorylation in response to CLIC5A. In J Cell Sci on 2014 Dec 15 by Abass Al-Momany, Laiji Li, et al..PMID:25344252
, (2014),
PMID:
25344252
et al,Clustered phosphatidylinositol 4, 5 bisphosphate accumulation and ezrin phosphorylation in response to CLIC5A. In J Cell Sci
on 2014 Dec 15 by Abass Al-Momany, Laiji Li,et al..PMID:25344252
, (2014),
PMID:
25344252
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