产品详情
产品名称p21Cip1(Phospho-Thr145) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用IHC
种属反应性Human
特异性The antibody detects endogenous level of p21Cip1 only when phosphorylated at threonine 145.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1.
基因/蛋白名称p21Cip1
标记Unconjugated
别名CAP20; CDK-interacting protein 1; CDKN1; CDKN1A; CDN1A
数据库入口号Swiss-Prot: P38936
NCBI Protein: NP _000380.1
Uniprot
P38936
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 21kd
Immunohistochemistry: 1:50~1:100
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p21Cip1(Phospho-Thr145) Antibody #11206(left) or the same antibody preincubated with blocking peptide(right).
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
Ocker M Int,et al. (2007)J Biochem Cell Biol. 39(7-8):1367-74.
Dangi S, et al.(2006)Cell Prolif. 39(4):261-79.
Chen J,et al.(2006)Am J Physiol Heart Circ Physiol. 290(4):H1575-86
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