产品详情
产品名称b-Catenin(Phospho-Ser37) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of b-Catenin only when phosphorylated at serine 37.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of serine 37 (I-H-S(p)-G-A) derived from Human b-Catenin.
基因/蛋白名称b-Catenin
标记Unconjugated
别名CTNNB1; CATNB; CTNB1; CTNNB;
数据库入口号Swiss-Prot: P35222
NCBI Protein: NP_001091679.1
Uniprot
P35222
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 92kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from HT29 cells using b-Catenin(Phospho-Ser37) Antibody #11219 and the same antibody preincubated with blocking peptide .
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using b-Catenin(Phospho-Ser37) Antibody #11219(left) or the same antibody preincubated with blocking peptide(right).
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
Novak A, et al. (1998) Proc Natl Acad Sci U S A; 95(8): 4374-4379
Marin O, et al. (2003) Proc Natl Acad Sci U S A; 100(18): 10193-10200
Okamura H, et al. (2004) Mol Cell Biol; 24(10): 4184-4195
Xing Y, et al. (2003) Genes Dev; 17(22): 2753-2764
Barth AI, et al. (1999) Proc Natl Acad Sci U S A; 96(9): 4947-4952
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et al,PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo.
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et al, Curcumin suppresses cell proliferation through inhibition of the Wnt/尾-catenin signaling pathway in medulloblastoma.In Oncol Rep on 2014 Jul by Misi He , Yu Li et al..PMID: 24858998
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