产品详情
产品名称c-Kit(Phospho-Tyr721) Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of c-Kit only when phosphorylated at tyrosine 721.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of tyrosine 721 (N-E-Y(p)-M-D) derived from Human c-Kit.
基因/蛋白名称c-Kit
标记Unconjugated
别名KIT , CD117, SCFR, PBT
数据库入口号Swiss-Prot: P10721
NCBI Protein: NP_000213.1
Uniprot
P10721
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 145kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Hela cells untreated or treated with IFN-a using c-Kit(Phospho-Tyr721) Antibody #11240.
This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
Nocka, K. et al. (1990) EMBO J. 9, 1805-1813.
Hirota, S. et al. (1998) Science 279, 577-580.
Blume-Jensen, P. et al. (2000) Nat. Genet. 24, 157-162.
Sattler, M. et al. (1997) J. Biol. Chem. 272, 10248-10253.
Gommerman, J.L. et al. (1997) J. Biol. Chem. 272, 30519-30525.
如果您使用该产品11240发表了文章，请通知我们，让我们可以引用您的文献。
et al,MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia.
, (2011),
PMID:
21724256
et al,MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. In Leuk Res on 2011 Sep by Xiao-ning Gao, Ji Lin,
et al..PMID: 21724256
, (2011),
PMID:
21724256
et al,MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. In Oncogene on 2011 Aug 4 by X-N Gao, J Lin, et al..PMID: 21399664
, (2011),
PMID:
21399664
et al,S-allyl cysteine ameliorates the quality of sperm and provides protection from age-related sperm dysfunction and oxidative stress in rats.In J Clin Biochem Nutr on 2014 Nov by Shigekazu Takemura, Hiroshi Ichikawa et al..PMID: 25411519
, (2014),
PMID:
25411519
et al,Stromal-derived MAOB promotes prostate cancergrowth and progression. In Sci Adv on 2024 Feb 9 by Tianjie Pu, Jing Wang,et al..PMID:38335292
, (2024),
PMID:
38335292
有货
