产品详情
产品名称STAT2(phospho-Tyr690) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from Human Stat2
基因/蛋白名称STAT2
标记Unconjugated
别名P113; ISGF-3; STAT113; MGC59816;
数据库入口号Swiss-Prot: P52630
NCBI Protein: NP_005410.1
Uniprot
P52630
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 113kd
Western blotting: 1:1000
Western blot analysis of extracts from Hela cells untreated or treated with IFN-a using Stat2(phospho-Tyr690) Antibody #11536.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has
been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992)
Yan R,et al. Nucleic Acids Res. 23:459-463(1995)
Fu X.Y.Cell 70:323-335(1992)
Sugiyama T,et al.FEBS Lett. 381:191-194(1996)
如果您使用该产品11536发表了文章，请通知我们，让我们可以引用您的文献。
et al,6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside Potentiates the Anti-Proliferative Effect of Interferon 伪/尾 by Promoting Activation of the JAK/STAT Signaling by Inhibiting SOCS3 in Hepatocellular Carcinoma Cells.In Toxicol Appl Pharmacol on 2017 Dec 1 by Orawan Wonganan, Yu-Jiao He,et al..PMID: 29031523
, (2017),
PMID:
29031523
et al,Expression of interferon effector gene SART1 correlates with interferon treatment response against hepatitis B infection. In Mediators Inflamm on 2016 by Yong Li, Chuanlong Zhu et al..PMID: 28077916
, (2016),
PMID:
28077916
et al,CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis.
, (2025),
PMID:
40122504
有货
