产品详情
产品名称Sufu(Phospho-Ser342) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of Serine 342 (A-P-S(p)-R-K) derived from Human Sufu.
基因/蛋白名称Sufu
标记Unconjugated
别名SUFUH
数据库入口号Swiss-Prot: Q9UMX1
NCBI Protein: NP_057253.2
Uniprot
Q9UMX1
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 54kd
Western blotting: 1:500~1:1000
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)
Zimmern P,et al.(2010) Neurourol Urodyn.29(5):715-8.
Wang C,et al. (2010) Development. 137(12):2001-9.
Rabasseda X.et al.(2010) Drug News Perspect.23(4):273-5.
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et al,Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium
, (2011),
PMID:
21317289
et al,Suppressor of Fused (Sufu) Mediates the Effect of Parathyroid Hormone-Like Hormone (Pthlh) on Chondrocyte Differentiation in the Growth Plate.In J Biol Chem on 2012 Oct 19 by Xiaoyun Zhang, Steven Cheng, et al..PMID:22930757
, (2012),
PMID:
22930757
et al,Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused. In Cell Death Dis on 2020 Aug 11 by Hengqing Liao, Jing Cai, et al..PMID:32826873
, (2020),
PMID:
32826873
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