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Tau (Phospho-Ser202) Antibody#11723

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产品详情

产品名称Tau (Phospho-Ser202) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Human

特异性The antibody detects endogenous levels of Tau only when phosphorylated at serine 202.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 202(P-G-S(p)-P-G) derived from Human Tau.

基因/蛋白名称Tau

标记Unconjugated

别名MAPT; MTBT1; PHF-tau;

数据库入口号Swiss-Prot#: P10636;
NCBI Gene#: 4137;
NCBI Protein#: NP_058519.3.

Uniprot P10636

实际分子量85kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000

Western blot analysis of extracts from JK cells (Lane 2), using Tau (Phospho-Ser202) Antibody #11723. The lane on the left is treated with antigen-specific peptide.

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Goedert M., EMBO J. 8:393-399(1989).
Lee G., Neuron 2:1615-1624(1989).

如果您使用该产品11723发表了文章,请通知我们,让我们可以引用您的文献。

et al,Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease.In Transl Psychiatry on 2016 Oct 4 by S-S Jiao , L-L Shen et al..PMID:27701410 , (2016),
PMID: 27701410

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

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