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位置: 首页 > 磷酸化抗体 > FGFR4 (Phospho-Tyr642) Antibody

FGFR4 (Phospho-Tyr642) Antibody#11836

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产品详情

产品名称FGFR4 (Phospho-Tyr642) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB,ELISA

种属反应性Human;Mouse;Rat

特异性The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .

基因/蛋白名称FGFR4

标记Unconjugated

别名FGFR-4; CD_antigen=CD334; Fibroblast growth factor receptor 4; EC=2.7.10.1;

数据库入口号Swiss-Prot#: P22455;
NCBI Gene#: 2264;
NCBI Protein#: NP_002002.3.

Uniprot P22455

实际分子量90kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Western blotting: 1:500~1:1000

Western blot analysis of extracts from JK cells (Lane 2), using FGFR4 (Phospho-Tyr642) Antibody #11836. The lane on the left is treated with antigen-specific peptide.

Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

Partanen J.M., EMBO J. 10:1347-1354(1991) [PubMed: 1709094].
Ron D., J. Biol. Chem. 268:5388-5394(1993) [PubMed: 7680645].
Takaishi S.,Biochem. Biophys. Res. Commun. 267:658-662(2000) [PubMed: 10631118].

如果您使用该产品11836发表了文章,请通知我们,让我们可以引用您的文献。

et al,Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer.In Oncol Rep on 2015 Nov by Lingling Hu , Lanxiang Cong.PMID:26323668 , (2015),
PMID: 26323668
et al,Loss of E-cadherin Activates a Targetable IGF1R Pathway in Invasive Lobular Breast Carcinoma. In Mol Cancer Res on 2022 Sep 2 by Ashuvinee Elangovan, Jagmohan Hooda,et al..PMID:35665642 , (2022),
PMID: 35665642
et al,Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma. In Mol Cancer Res on 2022 Sep 2 by Ashuvinee Elangovan, Jagmohan Hooda, et al..PMID:35665642 , (2022),
PMID: 35665642
et al,Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer. In bioRxiv [Preprint] on 2024 Mar 20 by Kai Ding, Lyuqin Chen, et al..PMID:38562741 , (2024),
PMID: 38562741
et al,FGFR4 in endocrine resistance: overexpression and estrogen regulation without direct causative role. , (2025),
PMID: 40097769

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

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