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位置: 首页 > 磷酸化抗体 > M-CSF Receptor (Phospho-Tyr809) Antibody

M-CSF Receptor (Phospho-Tyr809) Antibody#11906

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产品详情

产品名称M-CSF Receptor (Phospho-Tyr809) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Human

特异性The antibody detects endogenous level of M-CSF Receptor only when phosphorylated at tyrosine 809.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V) derived from Human M-CSF Receptor.

基因/蛋白名称M-CSF Receptor

标记Unconjugated

别名CSF1R; C-FMS; CD115; CSFR;

数据库入口号Swiss-Prot#: P07333;
NCBI Gene#: 1436;
NCBI Protein#: NP_001275634.1

Uniprot P07333

实际分子量108kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from 293 cells treated with LPS using Phospho-M-CSF Receptor (Tyr809) antibody #11906.The lane on the right is treated with the antigen-specific peptide.

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

Sampaio NG, et al. (2011) J Cell Sci 124, 2021-31
21610095 Curated Info
Xiong Y, et al. (2011) J Biol Chem 286, 952-60
21041311 Curated Info
Yu W, et al. (2008) J Leukoc Biol 84, 852-63

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注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

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