产品详情
产品名称FOXO4 (Phospho-Thr451) Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of FOXO4 only when phosphorylated at Threonine 451.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of Threonine 451
(L-G-T(p)-P-V) derived from Human FOXO4.
基因/蛋白名称FOXO4
标记Unconjugated
别名AFX, AFX1, MLLT7
数据库入口号Swiss-Prot#: P98177;
NCBI Gene#: 4303;
NCBI Protein#: NP_001164402.1
Uniprot
P98177
实际分子量65kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 65kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from HUVEC cells treated with EGF using FOXO4 (Phospho-Thr451) Antibody #12053.The lane on the left is treated with the antigen-specific peptide.
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
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et al,FoxO4 activity is regulated by phosphorylation and the cellular environment during dehydration in the African clawed frog, Xenopus laevis.On Int J Neurosci.On 2018 Dec by Zh o H, Liu Y et al..PMID:29883225
, (2018),
PMID:
29883225
et al,Inhibition of skeletal muscle atrophy during torpor in ground squirrels occurs through downregulation of MyoG and inactivation of Foxo4.In Cryobiology on 2016 Oct by Yichi Zhang , Shannon N Tessier et al..PMID:27593478
, (2016),
PMID:
27593478
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