产品详情
产品名称GR (Phospho-Ser203) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human
特异性The antibody detects endogenous level of GR only when phosphorylated at Serine 203.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of Serine 203
(S-G-S(p)-P-G) derived from Human GR.
基因/蛋白名称GR
标记Unconjugated
别名 GCCR, GCR, GR, GRL
数据库入口号Swiss-Prot#: P04150;
NCBI Gene#: 2908;
NCBI Protein#: NP_000167.1
Uniprot
P04150
实际分子量86kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 86kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from A549 cells using GR (Phospho-Ser203) Antibody #12062.The lane on the left is treated with the antigen-specific peptide.
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.
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