产品详情
产品名称Tau (Phospho-Ser516/199) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of Tau only when phosphorylated at serine 516/199.
免疫原类型peptide
免疫原描述Peptide sequence around phosphorylation site of serine 516/199 (Y-S-S(p)-P-G) derived from Human Tau.
基因/蛋白名称Tau
标记Unconjugated
别名MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
数据库入口号Swiss-Prot#:P10636;
NCBI Gene#:4137
Uniprot
P10636
实际分子量74kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from Mouse brain cells, using Tau (Phospho-Ser516/199) antibody #12123. The lane on the right is treated with the synthesized peptide.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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et al,NeurotrophIn receptor p75 mediates amyloid β-Induced tau pathology. In Neurobiol Dis on 2019 Dec by Shen LL, Li WW, et al..PMID:31394202
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et al,Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-β and Prevents Alzheimer's Disease-Type Pathology and Cognitive Deficits
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