产品详情
产品名称Tau(Phospho-T231) Rabbit mAb
克隆号SC58-08
来源种属Rabbit
克隆性Monoclonal
纯化ProA affinity purified
应用WB;ICC/IF;IHC
种属反应性Human;Mouse;Rat
免疫原描述Synthetic phospho-peptide corresponding to residues surrounding Thr231 of human Tau.
标记Unconjugated
别名AI413597 antibody
AW045860 antibody
DDPAC antibody
FLJ31424 antibody
FTDP 17 antibody
G protein beta1/gamma2 subunit interacting factor 1 antibody
MAPT antibody
MAPTL antibody
MGC134287 antibody
MGC138549 antibody
MGC156663 antibody
Microtubule associated protein tau antibody
Microtubule associated protein tau isoform 4 antibody
Microtubule-associated protein tau antibody
MSTD antibody
Mtapt antibody
MTBT1 antibody
MTBT2 antibody
Neurofibrillary tangle protein antibody
Paired helical filament tau antibody
Paired helical filament-tau antibody
PHF tau antibody
PHF-tau antibody
PPND antibody
PPP1R103 antibody
Protein phosphatase 1, regulatory subunit 103 antibody
pTau antibody
RNPTAU antibody
TAU antibody
TAU_HUMAN antibody
Tauopathy and respiratory failure, included antibody
数据库入口号Swiss-Prot#:P10636
Uniprot
P10636
计算分子量46 kDa
实际分子量48 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:2000
ICC/IF: 1:50-1:200
IHC: 1:50-1:200
All lanes : Tau(Phospho-T231) Rabbit mAb at 1/1k dilution
Lane 1 : SH-SY5Y whole cell lysates
Lane 2 : Rat brain tissue lysates
Lane 3 : Mouse brain tissue lysates
Lane 4 : Mouse brain treated with λpp for 1 hour tissue lysates
Lysates/proteins at 20 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution
Predicted band size: 46 kDa
Observed band size: 48 kDa
Exposure time: 9 seconds
Formalin-fixed;paraffin-embedded mouse brain tissue stained for Tau(Phospho-T231) using 13381 at 1/100 dilution in immunohistochemical analysis.
Immunocytochemistry/ Immunofluorescence Tau (Phospho-T231) antibody (13381)
ICC/IF staining of Tau (Phospho-T231 in SH-SY5Y cells. Cells were fixed with 4% Paraformaldehyde permeabilized with 0.1% Triton X-100.
Samples were incubated with 13381 at a working dilution of 1/100. The secondary antibody was Alexa Fluor® 647 goat anti rabbit;used at a dilution of 1/500.
Nuclei were counterstained with DAPI.
Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).
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